�-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression | Zendy

Jun Zhang | Zendy; He da Zhang | Zendy; Lin Chen | Zendy; Da Sun | Zendy; Chang fei Mao | Zendy; Wei Chen | Zendy; Jian Wu | Zendy; Shan Zhong | Zendy; Jian Zhao | Zendy; Jin Tang | Zendy

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�-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression

Author(s) -

Jun Zhang,

He da Zhang,

Lin Chen,

Da Sun,

Chang fei Mao,

Wei Chen,

Jian Wu,

Shan Zhong,

Jian Zhao,

Jin Tang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366398

Subject(s) - elemene , microrna , mcf 7 , multiple drug resistance , cancer research , pten , mtt assay , docetaxel , breast cancer , cancer , biology , pharmacology , cell growth , drug resistance , medicine , apoptosis , pi3k/akt/mtor pathway , gene , human breast , biochemistry , microbiology and biotechnology

Multidrug resistance (MDR) directly contributes to the clinical failure of chemotherapy in breast cancer (BCA). β-elemene is a natural antitumor drug from plants. We previously confirmed that MDR could be reversed by β-elemene. In this study, we intended to investigate the reversal effect of β-elemene on MDR in human BCA adriacin (Adr) -resistant MCF-7 cells (MCF-7/Adr) and docetaxel (Doc) - resistant MCF-7 cells (MCF-7/Doc) through the gene regulatory network.

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