The Inactivation of JAK2/STAT3 Signaling and Desensitization of M1 mAChR in Minimal Hepatic Encephalopathy (MHE) and the Protection of Naringin Against MHE | Zendy

Saidan Ding | Zendy; Jiangnan Hu | Zendy; Jianjing Yang | Zendy; Leping Liu | Zendy; Weilong Huang | Zendy; Xialong Gu | Zendy; Yiru Ye | Zendy; Lijie Huang | Zendy; Yong Liang | Zendy; Bicheng Chen | Zendy; Qichuan Zhuge | Zendy

Open Access

The Inactivation of JAK2/STAT3 Signaling and Desensitization of M1 mAChR in Minimal Hepatic Encephalopathy (MHE) and the Protection of Naringin Against MHE

Author(s) -

Saidan Ding,

Jiangnan Hu,

Jianjing Yang,

Leping Liu,

Weilong Huang,

Xialong Gu,

Yiru Ye,

Lijie Huang,

Yong Liang,

Bicheng Chen,

Qichuan Zhuge

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366391

Subject(s) - choline acetyltransferase , hepatic encephalopathy , muscarinic acetylcholine receptor , medicine , endocrinology , cholinergic , pathogenesis , acetylcholine , chemistry , neuroscience , biology , receptor , cirrhosis

We previously reported that elevation of intracranial dopamine (DA) levels from cirrhotic livers is implicated in the pathogenesis of minimal hepatic encephalopathy (MHE). Intracellular events in neurons, which lead to memory loss in MHE by elevated DA, however, remain elusive.

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