Hypercholesterolemia Increases the Production of Leukotriene B4 in Neutrophils by Enhancing the Nuclear Localization of 5-Lipoxygenase | Zendy

Xiaofeng Lai | Zendy; Hua-Di Qin | Zendy; Leilei Guo | Zendy; Ziguo Luo | Zendy; Jing Chang | Zendy; Chunchang Qin | Zendy

Open Access

Hypercholesterolemia Increases the Production of Leukotriene B4 in Neutrophils by Enhancing the Nuclear Localization of 5-Lipoxygenase

Author(s) -

Xiaofeng Lai,

Hua-Di Qin,

Leilei Guo,

Ziguo Luo,

Jing Chang,

Chunchang Qin

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366373

Subject(s) - leukotriene b4 , medicine , stimulation , lipopolysaccharide , endocrinology , arachidonate 5 lipoxygenase , leukotriene , inflammation , cholesterol , autocrine signalling , chemistry , activator (genetics) , biology , receptor , biochemistry , arachidonic acid , enzyme , asthma

Neutrophils can synthesize leukotriene B4 (LTB4) by activating the 5-lipoxygenase (5-LO)signaling pathway. LTB4 is a pro-inflammatory mediator associated with the etiology and progression of atherosclerosis. It can increase function and number of neutrophils in an autocrine manner. Since hypercholesterolemia is associated with an increase in the number and function of neutrophils, we hypothesized that this effect could be mediated through increased production of LTB4 in neutrophils.

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