WWOX Suppresses Cell Growth and Induces Cell Apoptosis via Inhibition of P38 Nuclear Translocation in Cholangiocarcinoma | Zendy

Mei Wang | Zendy; Yongmei Li | Zendy; Meihong Wu | Zendy; Wei Wang | Zendy; Biao Gong | Zendy; Yajie Wang | Zendy

Open Access

WWOX Suppresses Cell Growth and Induces Cell Apoptosis via Inhibition of P38 Nuclear Translocation in Cholangiocarcinoma

Author(s) -

Mei Wang,

Yongmei Li,

Meihong Wu,

Wei Wang,

Biao Gong,

Yajie Wang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366372

Subject(s) - wwox , cancer research , ectopic expression , apoptosis , p38 mitogen activated protein kinases , cell growth , biology , mapk/erk pathway , signal transduction , microbiology and biotechnology , cell culture , cancer , biochemistry , genetics , suppressor

Extrahepatic cholangiocarcinoma (EHCC) is the second most common primary hepatic malignancy, and is associated with high morbidity and mortality. We previously reported the decreased expression of WWOX in EHCC samples, but the underlying mechanism remained unclear.

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