MicroRNA-22 Induces Endothelial Progenitor Cell Senescence by Targeting AKT3 | Zendy

Yue Zheng | Zendy; Zhiwei Xu | Zendy

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MicroRNA-22 Induces Endothelial Progenitor Cell Senescence by Targeting AKT3

Author(s) -

Yue Zheng,

Zhiwei Xu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366358

Subject(s) - senescence , endothelial progenitor cell , angiogenesis , progenitor cell , matrigel , gene silencing , cell growth , neovascularization , biology , microbiology and biotechnology , microrna , cancer research , stem cell , downregulation and upregulation , genetics , gene

Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization. The number and function of EPCs declines as part of aging-associated senescence, thereby potentially contributing to vascular pathologies. Here, we investigated the significance and molecular mechanisms of microRNA-22 (miR-22) governing EPC senescence.

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