The Putative Role of the Non-Gastric H+/K+-ATPase ATP12A (ATP1AL1) as Anti-Apoptotic Ion Transporter: Effect of the H+/K+ATPase Inhibitor SCH28080 on Butyrate-Stimulated Myelomonocytic HL-60 Cells | Zendy

Martin Jakab | Zendy; Sabine Hofer | Zendy; Andrea Ravasio | Zendy; Felix Huber | Zendy; Sabine Schmidt | Zendy; Wolfgang Hitzl | Zendy; John P. Geibel | Zendy; Johannes Fürst | Zendy; Markus Ritter | Zendy

Open Access

The Putative Role of the Non-Gastric H⁺/K⁺-ATPase ATP12A (ATP1AL1) as Anti-Apoptotic Ion Transporter: Effect of the H⁺/K⁺ATPase Inhibitor SCH28080 on Butyrate-Stimulated Myelomonocytic HL-60 Cells

Author(s) -

Martin Jakab,

Sabine Hofer,

Andrea Ravasio,

Felix Huber,

Sabine Schmidt,

Wolfgang Hitzl,

John P. Geibel,

Johannes Fürst,

Markus Ritter

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366355

Subject(s) - microbiology and biotechnology , apoptosis , symporter , phosphatidylserine , intracellular , flow cytometry , biology , atpase , intracellular ph , butyrate , chemistry , biochemistry , transporter , membrane , gene , enzyme , phospholipid , fermentation

The ATP12A gene codes for a non-gastric H(+)/K(+) ATPase, which is expressed in a wide variety of tissues. The aim of this study was to test for the molecular and functional expression of the non-gastric H(+)/K(+) ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H(+)/K(+) ATPase inhibitor SCH28080 in apoptosis.

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