Phenotypic Modulation of Mesenteric Vascular Smooth Muscle Cells from Type 2 Diabetic Rats is Associated with Decreased Caveolin-1 Expression | Zendy

Maria Alícia Carrillo-Sepúlveda | Zendy; Takayuki Matsumoto | Zendy

Open Access

Phenotypic Modulation of Mesenteric Vascular Smooth Muscle Cells from Type 2 Diabetic Rats is Associated with Decreased Caveolin-1 Expression

Author(s) -

Maria Alícia Carrillo-Sepúlveda,

Takayuki Matsumoto

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366354

Subject(s) - calponin , vascular smooth muscle , endocrinology , medicine , mesenteric arteries , downregulation and upregulation , caveolin 1 , biology , reactive oxygen species , proliferating cell nuclear antigen , microbiology and biotechnology , artery , biochemistry , immunohistochemistry , smooth muscle , gene

Diabetes-induced vascular complications are associated with vascular smooth muscle cell (VSMC) phenotypic modulation, switching from a contractile to a synthetic-proliferative phenotype. Loss of caveolin-1 is involved with proliferation of VSMCs. We tested the hypothesis that mesenteric VSMCs from type 2 diabetic Goto-Kakizaki (GK) rat undergo phenotypic modulation and it is linked to decreased caveolin-1 expression.

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