Panax QuinquefoliumSaponin Attenuates Cardiomyocyte Apoptosis and Opening of the Mitochondrial Permeability Transition Pore in a Rat Model of Ischemia/Reperfusion | Zendy

Dong Li | Zendy; Mi Liu | Zendy; Tianqi Tao | Zendy; Dandan Song | Zendy; Xiuhua Liu | Zendy; Dazhuo Shi | Zendy

Open Access

Panax QuinquefoliumSaponin Attenuates Cardiomyocyte Apoptosis and Opening of the Mitochondrial Permeability Transition Pore in a Rat Model of Ischemia/Reperfusion

Author(s) -

Dong Li,

Mi Liu,

Tianqi Tao,

Dandan Song,

Xiuhua Liu,

Dazhuo Shi

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366347

Subject(s) - mitochondrial permeability transition pore , mptp , apoptosis , cytochrome c , chemistry , downregulation and upregulation , pharmacology , mitochondrion , reperfusion injury , cardioprotection , bcl 2 associated x protein , cytosol , caspase 3 , ischemia , endocrinology , biology , medicine , biochemistry , programmed cell death , dopaminergic , gene , dopamine , enzyme

Opening of the mitochondrial permeability transition pore (mPTP) is a critical event during ischemia/reperfusion (I/R) injury. Recently, we showed that Panax quinquefolium saponin (PQS) alleviates apoptosis of cardiomyocytes by suppressing excessive endoplasmic reticulum stress (ERS) during I/R injury. Here, we hypothesized that this anti-apoptotic effect might be mediated through inhibition of mPTP and the mitochondrial apoptotic pathway.

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