Formononetin Promotes Cell Cycle Arrest via Downregulation of Akt/Cyclin D1/CDK4 in Human Prostate Cancer Cells | Zendy

Tianyu Li | Zendy; Xinge Zhao | Zendy; Zengnan Mo | Zendy; Weihua Huang | Zendy; Haibiao Yan | Zendy; Zhian Ling | Zendy; Yu Ye | Zendy

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Formononetin Promotes Cell Cycle Arrest via Downregulation of Akt/Cyclin D1/CDK4 in Human Prostate Cancer Cells

Author(s) -

Tianyu Li,

Xinge Zhao,

Zengnan Mo,

Weihua Huang,

Haibiao Yan,

Zhian Ling,

Yu Ye

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366342

Subject(s) - downregulation and upregulation , protein kinase b , prostate cancer , formononetin , cell cycle checkpoint , cyclin d1 , cancer research , cell cycle , cyclin dependent kinase 6 , prostate , cyclin , cyclin d , chemistry , cancer , microbiology and biotechnology , medicine , biology , signal transduction , biochemistry , daidzein , genistein , gene

Formononetin is an O-methylated isoflavone isolated from the root of Astragalus membranaceus. It has already been reported that formononetin could inhibit cell proliferation and induce cell apoptosis in several cancers, including prostate cancer. This study aimed to further investigate whether cell cycle arrest is involved in formononetin-mediated antitumor effect in human prostate cancer cells, along with the underlying molecular mechanism.

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