A Novel Controllable Hydrogen Sulfide-Releasing Molecule Protects Human Skin Keratinocytes Against Methylglyoxal-Induced Injury and Dysfunction | Zendy

Chuntao Yang | Zendy; Yu Zhao | Zendy; Ming Xian | Zendy; Jianhua Li | Zendy; Qi Dong | Zendy; Hong-bo Bai | Zendy; Ji-de Xu | Zendy; Meifen Zhang | Zendy

Open Access

A Novel Controllable Hydrogen Sulfide-Releasing Molecule Protects Human Skin Keratinocytes Against Methylglyoxal-Induced Injury and Dysfunction

Author(s) -

Chuntao Yang,

Yu Zhao,

Ming Xian,

Jianhua Li,

Qi Dong,

Hong-bo Bai,

Ji-de Xu,

Meifen Zhang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366339

Subject(s) - hacat , methylglyoxal , viability assay , keratinocyte , reactive oxygen species , oxidative stress , apoptosis , microbiology and biotechnology , wound healing , medicine , pharmacology , chemistry , biochemistry , in vitro , immunology , biology , enzyme

Delayed wound healing is a common skin complication of diabetes, which is associated with keratinocyte injury and dysfunction. Levels of methylglyoxal (MGO), an α-dicarbonyl compound, are elevated in diabetic skin tissue and plasma, while levels of hydrogen sulfide (H2S), a critical gaseous signaling molecule, are reduced. Interestingly, the gas has shown dermal protection in our previous study. To date, there is no evidence demonstrating whether MGO affects keratinocyte viability and function or H2S donation abolishes these effects and improves MGO-related impairment of wound healing. The current study was conducted to examine the effects of MGO on the injury and function in human skin keratinocytes and then to evaluate the protective action of a novel H2S-releasing molecule.

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