Functional Expression and Regulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels (HCN) in Mouse iPS Cell-derived Cardiomyocytes afterUTF1-Neo Selection | Zendy

Judith Semmler | Zendy; Martin Lehmann | Zendy; Kurt Pfannkuche | Zendy; Michael Reppel | Zendy; Jürgen Hescheler | Zendy; Filomain Nguemo | Zendy

Open Access

Functional Expression and Regulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels (HCN) in Mouse iPS Cell-derived Cardiomyocytes afterUTF1-Neo Selection

Author(s) -

Judith Semmler,

Martin Lehmann,

Kurt Pfannkuche,

Michael Reppel,

Jürgen Hescheler,

Filomain Nguemo

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366332

Subject(s) - microbiology and biotechnology , biology , reprogramming , transplantation , hyperpolarization (physics) , transcription factor , electrophysiology , myocyte , hcn channel , membrane potential , ion channel , cell , chemistry , neuroscience , gene , medicine , genetics , receptor , organic chemistry , nuclear magnetic resonance spectroscopy

In vitro reprogramming of somatic cells holds great potential to serve as an autologous source of cells for tissue repair. However, major difficulties in achieving this potential include obtaining homogeneous and stable cells for transplantation. High electrical activity of cells such as cardiomyocytes (CMs) is crucial for both, safety and efficiency of cell replacement therapy. Moreover, the function of the cardiac pacemaker is controlled by the activities of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Here we have examined changes in HCN gene expression and function during cardiomyogenesis.

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