Cajaninstilbene Acid Prevents Corticosterone-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondrial Apoptotic Pathway | Zendy

Baoping Jiang | Zendy; Yamin Liu | Zendy; Liang Le | Zendy; Zongyang Li | Zendy; Jianyong Si | Zendy; Xinmin Liu | Zendy; Qi Chang | Zendy; RuiLe Pan | Zendy

Open Access

Cajaninstilbene Acid Prevents Corticosterone-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondrial Apoptotic Pathway

Author(s) -

Baoping Jiang,

Yamin Liu,

Liang Le,

Zongyang Li,

Jianyong Si,

Xinmin Liu,

Qi Chang,

RuiLe Pan

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366317

Subject(s) - icad , apoptosis , viability assay , mitochondrial permeability transition pore , dna fragmentation , cytochrome c , microbiology and biotechnology , propidium iodide , biology , mtt assay , intracellular , cytotoxicity , biochemistry , programmed cell death , chemistry , in vitro

Cajaninstilbene acid (3-hydroxy-4-prenyl-5-methoxystilben-2 -carboxylic acid, CSA), a natural stilbene isolated from the leaves of Cajanus cajan, has attracted considerable attention for its wide range of pharmacological activities. This study investigated whether CSA protects against corticosterone (CORT)-induced injury in PC12 cells and examined the potential mechanisms underlying this protective effect.

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