Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux | Zendy

Carmela Iosco | Zendy; Cristina Cosentino | Zendy; Laura Sirna | Zendy; Roberta Romanò | Zendy; Silvia Cursano | Zendy; Alessandra Mongia | Zendy; Giampaolo Pompeo | Zendy; Julie Di Bernardo | Zendy; Claudio Ceccarelli | Zendy; Giovanni Tallini | Zendy; Kerry J. Rhoden | Zendy

Open Access

Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux

Author(s) -

Carmela Iosco,

Cristina Cosentino,

Laura Sirna,

Roberta Romanò,

Silvia Cursano,

Alessandra Mongia,

Giampaolo Pompeo,

Julie Di Bernardo,

Claudio Ceccarelli,

Giovanni Tallini,

Kerry J. Rhoden

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366313

Subject(s) - chemistry , pendrin , follicular cell , calcium , thyroid , medicine , endocrinology , biology , biochemistry , transporter , organic chemistry , gene

Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified. A calcium-activated pathway of iodide efflux has long been recognized, but its molecular identity unknown. Anoctamin 1 (ANO1) is a calcium-activated chloride channel (CaCC), and this study aims to investigate its contribution to iodide fluxes in thyroid cells.

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