By Targeting Stat3 microRNA-17-5p Promotes Cardiomyocyte Apoptosis in Response to Ischemia Followed by Reperfusion | Zendy

Weijie Du | Zendy; Zhenwei Pan | Zendy; Xu Chen | Zendy; Leimin Wang | Zendy; Ying Zhang | Zendy; Shuang Li | Zendy; Haihai Liang | Zendy; Chaoqian Xu | Zendy; Yong Zhang | Zendy; Yanping Wu | Zendy; Hongli Shan | Zendy; Yanjie Lu | Zendy

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By Targeting Stat3 microRNA-17-5p Promotes Cardiomyocyte Apoptosis in Response to Ischemia Followed by Reperfusion

Author(s) -

Weijie Du,

Zhenwei Pan,

Xu Chen,

Leimin Wang,

Ying Zhang,

Shuang Li,

Haihai Liang,

Chaoqian Xu,

Yong Zhang,

Yanping Wu,

Hongli Shan,

Yanjie Lu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366312

Subject(s) - apoptosis , viability assay , stat3 , tunel assay , microbiology and biotechnology , western blot , microrna , reperfusion injury , chemistry , antagomir , biology , ischemia , medicine , biochemistry , gene

Several studies have confirmed the role of microRNAs in regulating ischemia/reperfusion-induced cardiac injury (I/R-I). MiR-17-5p has been regarded as an oncomiR in the development of cancer. However, its potential role in cardiomyocytes has not been exploited. The aim of this study is to investigate the role of miR-17-5p in I/R-I and the underlying mechanism through targeting Stat3, a key surviving factor in cardiomyocytes.

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