Serum- and Glucocorticoid-Inducible Kinase 1 Sensitive NF-&#954;B Signaling in Dendritic Cells | Zendy

Evi Schmid | Zendy; Nguyễn Thị Xuân | Zendy; Naima Zahir | Zendy; Antonella Russo | Zendy; Wenting Yang | Zendy; Dietmar Kuhl | Zendy; Caterina Faggio | Zendy; Ekaterina Shumilina | Zendy; Florian Läng | Zendy

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Serum- and Glucocorticoid-Inducible Kinase 1 Sensitive NF-κB Signaling in Dendritic Cells

Author(s) -

Evi Schmid,

Nguyễn Thị Xuân,

Naima Zahir,

Antonella Russo,

Wenting Yang,

Dietmar Kuhl,

Caterina Faggio,

Ekaterina Shumilina,

Florian Läng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366311

Subject(s) - sgk1 , biology , microbiology and biotechnology , cd86 , kinase , dendritic cell , phosphorylation , transcription factor , iκbα , iκb kinase , signal transduction , immune system , nf κb , t cell , immunology , biochemistry , gene

Dendritic cells (DCs), antigen-presenting cells linking innate and adaptive immunity, are required for initiation of specific T cell-driven immune responses. Phosphoinositide-3-kinase (PI3K) suppresses proinflammatory cytokine production in DCs, which limits T helper (Th1) polarization. PI3K is in part effective by downregulation of transcription factor NF-κB. Downstream signaling elements of PI3K include serum- and glucocorticoid-inducible kinase 1 (SGK1) and its phosphorylation target N-myc downstream regulated gene 1 (NDRG1). The present study explored whether SGK1 and NDRG1 play a role in the regulation of NF-κB and DC-maturation.

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