FSL-1 Induces MMP-9 Production through TLR-2 and NF-&#954;B /AP-1 Signaling Pathways in Monocytic THP-1 Cells | Zendy

Rasheed Ahmad | Zendy; Puthiyaveetil Kochumon Shihab | Zendy; Sara Jasem | Zendy; Kazem Behbehani | Zendy

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FSL-1 Induces MMP-9 Production through TLR-2 and NF-κB /AP-1 Signaling Pathways in Monocytic THP-1 Cells

Author(s) -

Rasheed Ahmad,

Puthiyaveetil Kochumon Shihab,

Sara Jasem,

Kazem Behbehani

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366310

Subject(s) - thp1 cell line , signal transduction , mapk/erk pathway , triptolide , nf κb , microbiology and biotechnology , gene knockdown , tlr2 , p38 mitogen activated protein kinases , cytokine , iκbα , biology , chemistry , cell culture , immunology , tlr4 , apoptosis , biochemistry , genetics

Matrix metalloproteinase-9 (MMP-9) is known to be implicated in the pathogenesis of many inflammatory disorders. FSL-1 (fibroblast-stimulating lipopeptide-1) induces cytokine production by monocytes/macrophages. However, it is unclear whether FSL-1 is also able to induce MMP-9 production. Herein, we determined whether FSL-1 could induce MMP-9 production, and if so, which signal transduction pathway(s) were involved.

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