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Therapeutic Effect of Alprostadil in Diabetic Nephropathy: Possible Roles of Angiopoietin-2 and IL-18
Author(s) -
Changqing Luo,
Ting Li,
Chun Zhang,
Qing Chen,
Zhenqiong Li,
Jianshe Liu,
Yumei Wang
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000366309
Subject(s) - diabetic nephropathy , western blot , angiopoietin , endocrinology , kidney , intraperitoneal injection , medicine , pathogenesis , diabetes mellitus , angiogenesis , streptozotocin , proteinuria , chemistry , pharmacology , vascular endothelial growth factor , gene , biochemistry , vegf receptors
To investigate the role of angiopoietin-2 (Ang-2) and IL-18 in the pathogenesis of diabetic nephropathy (DN) and the molecular mechanisms through which alprostadil protects renal function.

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