Open AccessAn Update on <b><i>Helicobacter pylori</i></b> as the Cause of Gastric Cancer
Author(s) -
Wei Zhang,
Hong Lü,
David Y. Graham
Publication year - 2014
Publication title -
gastrointestinal tumors
Language(s) - English
Resource type - Journals
eISSN - 2296-3766
pISSN - 2296-3774
DOI - 10.1159/000365310
Subject(s) - helicobacter pylori , cancer , inflammation , biology , medicine , immunology
Gastric cancer is the second most common cause of cancer deaths worldwide. The vast majority of gastric cancers are inflammation-related cancers caused by infection with Helicobacter pylori. H. pylori-induced oxidative stress damages DNA, resulting in genetic instability. In addition, H. pylori itself can cause DNA damage and epigenetic changes that trigger genetic instability and neoplastic transformation.
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