Vasoactive Intestinal Peptide-Deficient Mice Exhibit Reduced Pathology in Trinitrobenzene Sulfonic Acid-Induced Colitis | Zendy

Catalina Abad | Zendy; Gardenia Cheung-Lau | Zendy; Anne-Claire Coûté-Monvoisin | Zendy; James A. Waschek | Zendy

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Vasoactive Intestinal Peptide-Deficient Mice Exhibit Reduced Pathology in Trinitrobenzene Sulfonic Acid-Induced Colitis

Author(s) -

Catalina Abad,

Gardenia Cheung-Lau,

Anne-Claire Coûté-Monvoisin,

James A. Waschek

Publication year - 2014

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000364912

Subject(s) - vasoactive intestinal peptide , colitis , inflammatory bowel disease , tumor necrosis factor alpha , lipopolysaccharide , cytokine , immunology , endocrinology , inflammation , medicine , interleukin , neuropeptide , receptor , disease

Vasoactive intestinal peptide (VIP) is an immunomodulatory neuropeptide with therapeutic properties in multiple murine models of inflammatory disease including the trinitrobenzene-sulfonic acid (TNBS)-colitis model of Crohn's disease. Understanding the spectrum of biological actions of endogenously produced VIP may help us dissect the complex and multifactorial pathogenesis of such inflammatory diseases. Our goal was to determine the contribution of endogenously produced VIP to TNBS-colitis by using VIP knockout (KO) mice.

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