Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A | Zendy

Monika MajewskaSzczepanik | Zendy; Anna Strzępa | Zendy; Katarzyna Marcińska | Zendy; Wen Li | Zendy; Marian Szczepanik | Zendy

Open Access

Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A

Author(s) -

Monika MajewskaSzczepanik,

Anna Strzępa,

Katarzyna Marcińska,

Wen Li,

Marian Szczepanik

Publication year - 2014

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000363446

Subject(s) - immunology , zymosan , immunization , t cell receptor , medicine , antigen , t cell , biology , immune system , in vitro , biochemistry

Our previous work showed that epicutaneous (EC) immunization with protein antigen e.g. TNP-conjugated mouse immunoglobulin (TNP-Ig) in the form of a patch prior to hapten sensitization inhibits Th1-mediated contact hypersensitivity (CHS) in mice. We also found that suppression of CHS was mediated by TCRαβ+ CD4+ CD8+ T suppressor cells producing TGF-β. The aim of this study was to investigate the role of innate immunity in the suppression of CHS.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research