Association of Common Genetic Variants with Diabetes and Metabolic Syndrome Related Traits in the Arizona Insulin Resistance Registry: A Focus on Mexican American Families in the Southwest | Zendy

Jacob DeMenna | Zendy; Sobha Puppala | Zendy; Geetha Chittoor | Zendy; Jennifer L. Schneider | Zendy; Joon Young Kim | Zendy; Gabriel Q. Shaibi | Zendy; Lawrence J. Mandarino | Zendy; Ravindranath Duggirala | Zendy; Dawn K. Coletta | Zendy

Open Access

Association of Common Genetic Variants with Diabetes and Metabolic Syndrome Related Traits in the Arizona Insulin Resistance Registry: A Focus on Mexican American Families in the Southwest

Author(s) -

Jacob DeMenna,

Sobha Puppala,

Geetha Chittoor,

Jennifer L. Schneider,

Joon Young Kim,

Gabriel Q. Shaibi,

Lawrence J. Mandarino,

Ravindranath Duggirala,

Dawn K. Coletta

Publication year - 2014

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000363411

Subject(s) - single nucleotide polymorphism , genome wide association study , insulin resistance , heritability , type 2 diabetes , metabolic syndrome , obesity , medicine , body mass index , genetic association , diabetes mellitus , biology , genetics , endocrinology , genotype , gene

The increased occurrence of type 2 diabetes and its clinical correlates is a global public health issue, and there are continued efforts to find its genetic determinant across ethnically diverse populations. The aims of this study were to determine the heritability of diabetes and metabolic syndrome phenotypes in the Arizona Insulin Resistance (AIR) registry and to perform an association analysis of common single nucleotide polymorphisms (SNPs) identified by GWAS with these traits. All study participants were Mexican Americans from the AIR registry.

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