DAX-1 Inhibits Hepatocellular Carcinoma Proliferation by Inhibiting β-Catenin Transcriptional Activity | Zendy

Honglei Jiang | Zendy; Dong Xu | Zendy; Hao Yu | Zendy; Xu Ma | Zendy; Guofu Lin | Zendy; Dongyan Ma | Zendy; Junzhe Jin | Zendy

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DAX-1 Inhibits Hepatocellular Carcinoma Proliferation by Inhibiting β-Catenin Transcriptional Activity

Author(s) -

Honglei Jiang,

Dong Xu,

Hao Yu,

Xu Ma,

Guofu Lin,

Dongyan Ma,

Junzhe Jin

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363038

Subject(s) - biology , gene knockdown , cancer research , cell growth , small interfering rna , cell cycle , cell culture , microbiology and biotechnology , cell , rna , gene , genetics

Hepatocellular carcinoma (HCC) represents the most common type of liver cancer. DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome, gene 1), an atypical member of the nuclear receptor family due to lack of classical DNA-binding domains, has been known for its fundamental roles in the development, especially in the sex determination and steroidogenesis. Previous studies also showed that DAX-1 played a critical role in endocrine and sex steroid-dependent neoplasms such as adrenocortical, pituitary, endometrial, and ovarian tumors. However, its biological roles in the development of HCC remain largely unexplored.

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