Positive Feedback Loop of Autocrine BDNF from Microglia Causes Prolonged Microglia Activation | Zendy

Xin Zhang | Zendy; Lulu Zeng | Zendy; Tingting Yu | Zendy; Yongming Xu | Zendy; Shaofeng Pu | Zendy; Dongping Du | Zendy; Wei Jiang | Zendy

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Positive Feedback Loop of Autocrine BDNF from Microglia Causes Prolonged Microglia Activation

Author(s) -

Xin Zhang,

Lulu Zeng,

Tingting Yu,

Yongming Xu,

Shaofeng Pu,

Dongping Du,

Wei Jiang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363036

Subject(s) - microglia , neurotrophic factors , brain derived neurotrophic factor , autocrine signalling , tumor necrosis factor alpha , proinflammatory cytokine , tropomyosin receptor kinase b , western blot , neuroscience , microbiology and biotechnology , chemistry , biology , immunology , medicine , inflammation , receptor , biochemistry , gene

Microglia, which represent the immune cells of the central nervous system (CNS), have long been a subject of study in CNS disease research. Substantial evidence indicates that microglial activation functions as a strong neuro-inflammatory response in neuropathic pain, promoting the release of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α. In addition, activated microglia release brain-derived neurotrophic factor (BDNF), which acts as a powerful cytokine. In this study, we performed a series of in vitro experiments to examine whether a positive autocrine feedback loop existed between microglia-derived BDNF and subsequent microglial activation as well as the mechanisms underlying this positive feedback loop.

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