Fibroblast Growth Factor 21 Protects Against High Glucose Induced Cellular Damage and Dysfunction of Endothelial Nitric-Oxide Synthase in Endothelial Cells | Zendy

Xiaomei Wang | Zendy; ShuangShuang Song | Zendy; Hang Xiao | Zendy; Pan Gao | Zendy; Xuejun Li | Zendy; Liangyi Si | Zendy

Open Access

Fibroblast Growth Factor 21 Protects Against High Glucose Induced Cellular Damage and Dysfunction of Endothelial Nitric-Oxide Synthase in Endothelial Cells

Author(s) -

Xiaomei Wang,

ShuangShuang Song,

Hang Xiao,

Pan Gao,

Xuejun Li,

Liangyi Si

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363031

Subject(s) - enos , protein kinase b , ampk , protein kinase a , medicine , endocrinology , viability assay , chemistry , fgf21 , nitric oxide , nitric oxide synthase type iii , phosphorylation , nitric oxide synthase , biology , biochemistry , fibroblast growth factor , cell , receptor

Fibroblast growth factor 21 (FGF21) is a powerful endocrine hormone modulating glucose and lipid metabolism and represents a promising drug for type 2 diabetes. The present study was to determine the effect of FGF21 on high glucose-induced damage and dysfunction in endothelial cells.

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