Dipalmitoleoylphosphoethanolamine as a PP2A Enhancer Obstructs Insulin Signaling by Promoting Ser/Thr Dephosphorylation of Akt | Zendy

Ayako Tsuchiya | Zendy; Takeshi Kanno | Zendy; Tomoyuki Nishizaki | Zendy

Open Access

Dipalmitoleoylphosphoethanolamine as a PP2A Enhancer Obstructs Insulin Signaling by Promoting Ser/Thr Dephosphorylation of Akt

Author(s) -

Ayako Tsuchiya,

Takeshi Kanno,

Tomoyuki Nishizaki

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363027

Subject(s) - glut4 , dephosphorylation , glucose uptake , protein phosphatase 2 , phosphorylation , glucose transporter , chemistry , insulin , intracellular , akt1 , 3t3 l1 , phosphatase , protein kinase b , insulin receptor , microbiology and biotechnology , biochemistry , endocrinology , biology , insulin resistance , adipocyte , adipose tissue

The phospholipid phosphatidylethanolamine is implicated in the regulation of a variety of cellular processes. The present study investigated the effect of phosphatidylethanolamines such as 1,2-diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE), 1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine (DLPE), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (DPPE) on protein phosphatases, Akt1/2 activity, GLUT4 mobilizations, and glucose uptake into cells.

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