GLP-2 Suppresses LPS-Induced Inflammation in Macrophages by Inhibiting ERK Phosphorylation and NF-κB Activation | Zendy

Shanshan Xie | Zendy; Bingrun Liu | Zendy; Shoupeng Fu | Zendy; Wei Wang | Zendy; Yunhou Yin | Zendy; Nan Li | Zendy; Wei Chen | Zendy; Juxiong Liu | Zendy; Dianfeng Liu | Zendy

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GLP-2 Suppresses LPS-Induced Inflammation in Macrophages by Inhibiting ERK Phosphorylation and NF-κB Activation

Author(s) -

Shanshan Xie,

Bingrun Liu,

Shoupeng Fu,

Wei Wang,

Yunhou Yin,

Nan Li,

Wei Chen,

Juxiong Liu,

Dianfeng Liu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363025

Subject(s) - inflammation , phosphorylation , mapk/erk pathway , nf κb , microbiology and biotechnology , nfkb1 , cancer research , signal transduction , chemistry , macrophage , medicine , biology , transcription factor , biochemistry , in vitro , gene

GLP-2 has been shown to exert anti-inflammatory effects, but the underlying molecular mechanisms remained undefined. As macrophages are important in the development and maintenance of inflammation, we investigated whether exogenous GLP-2 modulates the expression of pro-inflammatory proteins in LPS stimulated murine peritoneal macrophages.

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