Nicotine Induces the Production of IL-1� and IL-8 via the a7 nAChR/NF-κB Pathway in Human Periodontal Ligament Cells: anin VitroStudy | Zendy

Lizheng Wu | Zendy; Yongchuan Zhou | Zendy; Zhifei Zhou | Zendy; Yingfeng Liu | Zendy; Yudi Bai | Zendy; Xianghui Xing | Zendy; Xiaojing Wang | Zendy

Open Access

Nicotine Induces the Production of IL-1� and IL-8 via the a7 nAChR/NF-κB Pathway in Human Periodontal Ligament Cells: anin VitroStudy

Author(s) -

Lizheng Wu,

Yongchuan Zhou,

Zhifei Zhou,

Yingfeng Liu,

Yudi Bai,

Xianghui Xing,

Xiaojing Wang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363011

Subject(s) - pyrrolidine dithiocarbamate , nicotine , chemistry , periodontal fiber , nf κb , nicotinic acetylcholine receptor , pharmacology , interleukin , in vitro , periodontitis , nfkb1 , microbiology and biotechnology , acetylcholine receptor , receptor , signal transduction , medicine , biology , immunology , cytokine , biochemistry , transcription factor , dentistry , gene

Tobacco smoking is a major risk factor for the occurrence and progression of periodontitis. We previously demonstrated that nicotine could induce the expression of α7 nicotinic acetylcholine receptors (α7 nAChR) in human and rat periodontal tissues. To further examine the signal pathways mediated by α7 nAChR in periodontal ligament (PDL) cells, we investigated whether nicotine affects interleukin-1β (IL-1β) and interleukin-8 (IL-8) via the α7 nAChR/NF-κB pathway in human PDL cells.

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