Puerarin Facilitates T-Tubule Development of Murine Embryonic Stem Cell-Derived Cardiomyocytes | Zendy

Lu Wang | Zendy; Yurong Cui | Zendy; Ming Tang | Zendy; Xinwu Hu | Zendy; Hongyan Luo | Zendy; Jürgen Hescheler | Zendy; Jiaoya Xi | Zendy

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Puerarin Facilitates T-Tubule Development of Murine Embryonic Stem Cell-Derived Cardiomyocytes

Author(s) -

Lu Wang,

Yurong Cui,

Ming Tang,

Xinwu Hu,

Hongyan Luo,

Jürgen Hescheler,

Jiaoya Xi

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363007

Subject(s) - puerarin , microbiology and biotechnology , downregulation and upregulation , embryonic stem cell , caveolin 3 , stem cell , biology , chemistry , caveolae , biochemistry , medicine , signal transduction , pathology , gene , alternative medicine

The embryonic stem cell-derived cardiomyocytes (ES-CM) is one of the promising cell sources for repopulation of damaged myocardium. However, ES-CMs present immature structure, which impairs their integration with host tissue and functional regeneration. This study used murine ES-CMs as an in vitro model of cardiomyogenesis to elucidate the effect of puerarin, the main compound found in the traditional Chinese medicine the herb Radix puerariae, on t-tubule development of murine ES-CMs.

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