Akt2 Mediates TGF-�1-Induced Epithelial to Mesenchymal Transition by Deactivating GSK3�/Snail Signaling Pathway in Renal Tubular Epithelial Cells | Zendy

Aiping Lan | Zendy; Yongfen Qi | Zendy; Jie Du | Zendy

Open Access

Akt2 Mediates TGF-�1-Induced Epithelial to Mesenchymal Transition by Deactivating GSK3�/Snail Signaling Pathway in Renal Tubular Epithelial Cells

Author(s) -

Aiping Lan,

Yongfen Qi,

Jie Du

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363006

Subject(s) - epithelial–mesenchymal transition , ly294002 , small interfering rna , signal transduction , pi3k/akt/mtor pathway , protein kinase b , akt2 , gene knockdown , gsk 3 , transforming growth factor , chemistry , microbiology and biotechnology , biology , cancer research , transfection , cell culture , downregulation and upregulation , akt1 , biochemistry , genetics , gene

The epithelial-mesenchymal transition (EMT) induced by growth factors or cytokines, particularly transforming growth factor-β (TGF-β1), plays an important role in kidney tubulointerstitial injury. However, signaling pathways mediating TGF-β1-induced EMT are not precisely known. In this study, we examined the role of Akt2 on EMT.

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