Depletion of Thymosin �4 Promotes the Proliferation, Migration, and Activation of Human Hepatic Stellate Cells | Zendy

Yongtao Xiao | Zendy; Chun-Ying Qu | Zendy; Wensong Ge | Zendy; Baocan Wang | Zendy; Jianxin Wu | Zendy; Leiming Xu | Zendy; Yingwei Chen | Zendy

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Depletion of Thymosin �4 Promotes the Proliferation, Migration, and Activation of Human Hepatic Stellate Cells

Author(s) -

Yongtao Xiao,

Chun-Ying Qu,

Wensong Ge,

Baocan Wang,

Jianxin Wu,

Leiming Xu,

Yingwei Chen

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000363005

Subject(s) - hepatic stellate cell , cell migration , cell growth , pi3k/akt/mtor pathway , protein kinase b , western blot , vimentin , small interfering rna , microbiology and biotechnology , cancer research , fibrosis , hepatic fibrosis , chemistry , biology , cell , signal transduction , cell culture , transfection , immunology , immunohistochemistry , medicine , endocrinology , biochemistry , genetics , gene

It has recently been reported that thymosin beta-4 (Tβ4) has anti-fibrogenic effects in human hepatic stellate cells (HSCs) in vitro, but the mechanisms underlying these effects remain unclear. The aim of this study was to investigate the roles of Tβ4 in the proliferation, migration, and activation of HSCs.

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