Salvianolic Acid B Inhibited PPARγ Expression and Attenuated Weight Gain in Mice with High-Fat Diet-Induced Obesity | Zendy

Peijian Wang | Zendy; Shuyu Xu | Zendy; Wenzhang Li | Zendy; Fang Wang | Zendy; Zhen Yang | Zendy; Licheng Jiang | Zendy; Qiulin Wang | Zendy; Mingqing Huang | Zendy; Peng Zhou | Zendy

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Salvianolic Acid B Inhibited PPARγ Expression and Attenuated Weight Gain in Mice with High-Fat Diet-Induced Obesity

Author(s) -

Peijian Wang,

Shuyu Xu,

Wenzhang Li,

Fang Wang,

Zhen Yang,

Licheng Jiang,

Qiulin Wang,

Mingqing Huang,

Peng Zhou

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362999

Subject(s) - endocrinology , medicine , triglyceride , adipose tissue , adipocyte , peroxisome proliferator activated receptor , obesity , white adipose tissue , insulin tolerance test , salvia miltiorrhiza , chemistry , cholesterol , receptor , insulin resistance , traditional chinese medicine , insulin sensitivity , alternative medicine , pathology

Obesity contributes to the development of cardiometabolic disorders such as type 2 diabetes, fatty liver disease and cardiovascular disease. Salvianolic acid B (Sal B) is a molecule derived from the root of Salvia miltiorrhiza (Danshen), which is a traditional Chinese medicine that is widely used to treat cardiovascular diseases. However, the role of Sal B in obesity and obesity-related metabolic disorders is unknown. In this study, we aimed to investigate the effects of Sal B on high-fat diet-induced obesity and determine the possible mechanisms involved.

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