The Common Acid Sphingomyelinase Polymorphism p.G508R is Associated with Self-Reported Allergy | Zendy

Martin Reichel | Zendy; Tanja RichterSchmidinger | Zendy; Christiane Mühle | Zendy; Cosima Rhein | Zendy; Panagiotis Alexopoulos | Zendy; Sibylle G. Schwab | Zendy; Erich Gulbins | Zendy; Johannes Kornhuber | Zendy

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The Common Acid Sphingomyelinase Polymorphism p.G508R is Associated with Self-Reported Allergy

Author(s) -

Martin Reichel,

Tanja RichterSchmidinger,

Christiane Mühle,

Cosima Rhein,

Panagiotis Alexopoulos,

Sibylle G. Schwab,

Erich Gulbins,

Johannes Kornhuber

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362986

Subject(s) - acid sphingomyelinase , allergy , sphingomyelin , allele , ceramide , pathophysiology , immunology , odds ratio , medicine , inflammation , polymorphism (computer science) , lipid signaling , biology , endocrinology , gene , genetics , cholesterol , apoptosis

Acid sphingomyelinase (ASM) is a key regulator of ceramide-dependent signalling pathways. Among others, activation of ASM can be induced by CD95 or cytokine signalling and by cellular stress resulting from inflammation or infection. Increased ASM activity was observed in a variety of human diseases including inflammatory and neuropsychiatric disorders. We hypothesized that basal ASM activity might influence the susceptibility for common human diseases.

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