Regulation of the Inflammasome by Ceramide in Cystic Fibrosis Lungs | Zendy

Heike Grassmé | Zendy; Alexander Carpinteiro | Zendy; Michael J. Edwards | Zendy; Erich Gulbins | Zendy; Katrin Anne Becker | Zendy

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Regulation of the Inflammasome by Ceramide in Cystic Fibrosis Lungs

Author(s) -

Heike Grassmé,

Alexander Carpinteiro,

Michael J. Edwards,

Erich Gulbins,

Katrin Anne Becker

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362983

Subject(s) - inflammasome , ceramide , acid sphingomyelinase , inflammation , pyroptosis , occludin , biology , microbiology and biotechnology , cystic fibrosis transmembrane conductance regulator , caspase 1 , tight junction , cystic fibrosis , immunology , chemistry , cancer research , apoptosis , biochemistry , genetics

Cystic fibrosis (CF), the most common autosomal recessive disorder in Western countries, is characterized by chronic pulmonary inflammation, reduced mucociliary clearance, and increased susceptibility to infection. Our studies using Cftr-deficient mice and human CF specimens showed that ceramide accumulates in CF lungs and mediates increased cell death, susceptibility to infections, and inflammation.

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