Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats | Zendy

Yifang Chen | Zendy; Dingkun Gui | Zendy; Jianguo Chen | Zendy; Dongyuan He | Zendy; Yunling Luo | Zendy; Niansong Wang | Zendy

Open Access

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

Author(s) -

Yifang Chen,

Dingkun Gui,

Jianguo Chen,

Dongyuan He,

Yunling Luo,

Niansong Wang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362974

Subject(s) - endoplasmic reticulum , chop , podocyte , apoptosis , unfolded protein response , atf4 , microbiology and biotechnology , medicine , cancer research , endocrinology , chemistry , pharmacology , biology , kidney , biochemistry , proteinuria

Endoplasmic reticulum (ER) stress-induced podocyte apoptosis plays a critical role in the development of diabetic nephropathy (DN). Here, we tested the hypothesis that suppression of PERK-ATF4-CHOP pathway by Astragaloside IV (AS-IV) is associated with inhibition of ER stress-induced podocyte apoptosis in streptozotocin (STZ)-induced diabetic rats.

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