Up-Regulation of Hepatic Alpha-2-HS-Glycoprotein Transcription by TestosteroneviaAndrogen Receptor Activation | Zendy

Jakob Voelkl | Zendy; Tatsiana Pakladok | Zendy; Yun Lin | Zendy; Robert Viereck | Zendy; Aleksandra Lebedeva | Zendy; Damaris Kukuk | Zendy; Bernd J. Pichler | Zendy; Ioana Alesutan | Zendy; Florian Läng | Zendy

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Up-Regulation of Hepatic Alpha-2-HS-Glycoprotein Transcription by TestosteroneviaAndrogen Receptor Activation

Author(s) -

Jakob Voelkl,

Tatsiana Pakladok,

Yun Lin,

Robert Viereck,

Aleksandra Lebedeva,

Damaris Kukuk,

Bernd J. Pichler,

Ioana Alesutan,

Florian Läng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362968

Subject(s) - endocrinology , medicine , fetuin , androgen receptor , androgen , testosterone (patch) , biology , flutamide , chemistry , hormone , glycoprotein , prostate cancer , microbiology and biotechnology , cancer

Fetuin-A (alpha-2-HS-glycoprotein, AHSG), a liver borne plasma protein, contributes to the prevention of soft tissue calcification, modulates inflammation, reduces insulin sensitivity and fosters weight gain following high fat diet or ageing. In polycystic ovary syndrome, fetuin-A levels correlate with free androgen levels, an observation pointing to androgen sensitivity of fetuin-A expression. The present study thus explored whether the expression of hepatic fetuin-A is modified by testosterone.

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