4-Phenylbutyric Acid Increases GLUT4 Gene Expression through Suppression of HDAC5 but not Endoplasmic Reticulum Stress | Zendy

Hailong Hu | Zendy; Li Li | Zendy; Changlin Wang | Zendy; Hongjuan He | Zendy; Ke Mao | Zendy; Xiao Ma | Zendy; Ruoyu Shi | Zendy; Yuri Oh | Zendy; Fengwei Zhang | Zendy; Ying Lü | Zendy; Qiong Wu | Zendy; Ning Gu | Zendy

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4-Phenylbutyric Acid Increases GLUT4 Gene Expression through Suppression of HDAC5 but not Endoplasmic Reticulum Stress

Author(s) -

Hailong Hu,

Li Li,

Changlin Wang,

Hongjuan He,

Ke Mao,

Xiao Ma,

Ruoyu Shi,

Yuri Oh,

Fengwei Zhang,

Ying Lü,

Qiong Wu,

Ning Gu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362967

Subject(s) - glut4 , tunicamycin , endoplasmic reticulum , glucose transporter , myogenesis , biology , unfolded protein response , glucose uptake , endocrinology , microbiology and biotechnology , skeletal muscle , insulin

The chemical chaperone 4-phenylbutyric acid (4-PBA) has been shown to relieve endoplasmic reticulum (ER) stress. Therefore, it improves insulin sensitivity and promotes glucose metabolism in skeletal muscle. Glucose transporter type 4 (GLUT4), as a major glucose transporter protein, plays a central role in glucose metabolism. Until now, it has been unclear whether 4-PBA affects GLUT4 gene expression and thus, contributes to glucose metabolism.

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