Ubiquitin-Specific Peptidase USP22 Negatively Regulates the STAT Signaling Pathway by Deubiquitinating SIRT1 | Zendy

Ning Ao | Zendy; Yanyan Liu | Zendy; Hailiang Feng | Zendy; Xiaocui Bian | Zendy; Zhanwen Li | Zendy; Bei Gu | Zendy; Xiaomei Zhao | Zendy; Yuqin Liu | Zendy

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Ubiquitin-Specific Peptidase USP22 Negatively Regulates the STAT Signaling Pathway by Deubiquitinating SIRT1

Author(s) -

Ning Ao,

Yanyan Liu,

Hailiang Feng,

Xiaocui Bian,

Zhanwen Li,

Bei Gu,

Xiaomei Zhao,

Yuqin Liu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362964

Subject(s) - ubiquitin , acetylation , deubiquitinating enzyme , immunoprecipitation , biology , small interfering rna , microbiology and biotechnology , gene knockdown , signal transduction , transfection , chemistry , biochemistry , apoptosis , gene

The ubiquitin-specific peptidase USP22 mediates various cellular and organismal processes, such as cell growth, apoptosis, and tumor malignancy. However, the molecular mechanisms that regulate USP22 activity remain poorly understood. Here we identify STAT3 as a new USP22 interactor.

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