Differential Effects of Intravenous Anesthetics on PDGF-BB-Induced Vascular Smooth Muscle Cell Migration | Zendy

Miki Iida | Zendy; Kumiko Tanabe | Zendy; Osamu Kozawa | Zendy; Hiroki Iida | Zendy

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Differential Effects of Intravenous Anesthetics on PDGF-BB-Induced Vascular Smooth Muscle Cell Migration

Author(s) -

Miki Iida,

Kumiko Tanabe,

Osamu Kozawa,

Hiroki Iida

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362961

Subject(s) - platelet derived growth factor receptor , phosphorylation , protein kinase b , vascular smooth muscle , mapk/erk pathway , microbiology and biotechnology , pharmacology , medicine , endocrinology , biology , growth factor , receptor , smooth muscle

Intravenous anesthetics are used during the perioperative and/or postoperative period in critically ill patients. Vascular smooth muscle cells (VSMCs) play important roles in vascular injury repair or restenosis after intervention. We previously reported that platelet-derived growth factor (PDGF)-BB induces VSMC migration via extracellular signal-regulated kinase (ERK) and Akt in a VSMC line, A10 cells. In the present study, we investigated the effects of intravenous anesthetics on PDGF-BB-induced VSMC migration and the mechanism.

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