Transcriptional Regulation of Gene Expression by microRNAs as Endogenous Decoys of Transcription Factors | Zendy

Chunhui Cui | Zendy; Jinlong Yu | Zendy; Shuxin Huang | Zendy; Huiquan Zhu | Zendy; Zong-hai Huang | Zendy

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Transcriptional Regulation of Gene Expression by microRNAs as Endogenous Decoys of Transcription Factors

Author(s) -

Chunhui Cui,

Jinlong Yu,

Shuxin Huang,

Huiquan Zhu,

Zong-hai Huang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362952

Subject(s) - decoy , microrna , gene expression , chromatin immunoprecipitation , transcription factor , biology , luciferase , regulation of gene expression , reporter gene , transcriptional regulation , electrophoretic mobility shift assay , gene , chromatin , microbiology and biotechnology , genetics , promoter , transfection , receptor

MicroRNAs (miRNAs) are known to produce post-transcriptional repression of gene expression. In light of the ability of decoy oligodeocynucleotides (ODNs) to sequestrate transcription factors (TFs) and the similar double-stranded structure between decoy ODNs and miRNAs, we proposed that miRNAs might act as endogenous decoy molecules to produce transcriptional regulation of gene expression.

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