Physiology of Iron Metabolism
Author(s) -
Sophie WaldvogelAbramowski,
Gérard Waeber,
Christoph Gassner,
Andreas Buser,
Beat M. Frey,
Bernard Favrat,
JeanDaniel Tissot
Publication year - 2014
Publication title -
transfusion medicine and hemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000362888
Subject(s) - physiology , metabolism , intensive care medicine , medicine
A revolution occurred during the last decade in the comprehension of the physiology as well as in the physiopathology of iron metabolism. The purpose of this review is to summarize the recent knowledge that has accumulated, allowing a better comprehension of the mechanisms implicated in iron homeostasis. Iron metabolism is very fine tuned. The free molecule is very toxic; therefore, complex regulatory mechanisms have been developed in mammalian to insure adequate intestinal absorption, transportation, utilization, and elimination. 'Ironomics' certainly will be the future of the understanding of genes as well as of the protein-protein interactions involved in iron metabolism.
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