Effects of Psychotherapy on DNA Strand Break Accumulation Originating from Traumatic Stress | Zendy

Julia Morath | Zendy; María MorenoVillanueva | Zendy; Gilava Hamuni | Zendy; Stephan Kolassa | Zendy; Martina RufLeuschner | Zendy; Maggie Schauer | Zendy; Thomas Elbert | Zendy; Alexander Bürkle | Zendy; IrisTatjana Kolassa | Zendy

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Effects of Psychotherapy on DNA Strand Break Accumulation Originating from Traumatic Stress

Author(s) -

Julia Morath,

María MorenoVillanueva,

Gilava Hamuni,

Stephan Kolassa,

Martina RufLeuschner,

Maggie Schauer,

Thomas Elbert,

Alexander Bürkle,

IrisTatjana Kolassa

Publication year - 2014

Publication title -

psychotherapy and psychosomatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.531

H-Index - 98

eISSN - 1423-0348

pISSN - 0033-3190

DOI - 10.1159/000362739

Subject(s) - dna repair , dna damage , traumatic stress , dna , carcinogenesis , medicine , psychology , biology , cancer , clinical psychology , genetics

Previous research reveals an association between traumatic stress and an increased risk for numerous diseases, including cancer. At the molecular level, stress may increase carcinogenesis via increased DNA damage and impaired DNA repair mechanisms. We assessed DNA breakage in peripheral blood mononuclear cells from individuals with post-traumatic stress disorder (PTSD) and measured the cellular capacity to repair single-strand breaks after exposure to ionizing X-radiation. We also investigated the effect of psychotherapy on both DNA breakage and DNA repair.

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