Validation and Reference Ranges of Hair Cortisol Measurement in Healthy Children | Zendy

Gerard Noppe | Zendy; Elisabeth F. C. van Rossum | Zendy; Jan W. Koper | Zendy; Laura Manenschijn | Zendy; G.J. Bruining | Zendy; Yolanda B. de Rijke | Zendy; Erica L.T. van den Akker | Zendy

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Validation and Reference Ranges of Hair Cortisol Measurement in Healthy Children

Author(s) -

Gerard Noppe,

Elisabeth F. C. van Rossum,

Jan W. Koper,

Laura Manenschijn,

G.J. Bruining,

Yolanda B. de Rijke,

Erica L.T. van den Akker

Publication year - 2014

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000362519

Subject(s) - medicine , circadian rhythm , hair care , endocrinology , biomarker , bone age , physiology , pediatrics , biology , biochemistry , chemistry , polymer science

Cortisol is produced in a circadian rhythm controlled by the hypothalamus-pituitary-adrenal axis, making it cumbersome to measure long-term cortisol exposure. Hair has proven to be a reliable matrix for long-term cortisol measurement in adults and can be used as diagnostic tool for (cyclic) Cushing's syndrome. The diagnostic applicability in children has not been studied, nor have the effects of development and hair care been evaluated in children. We aimed to establish reference ranges of hair cortisol concentrations (HCC) in healthy children and to evaluate the effects of age, gender, puberty and characteristics of hair care.

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