Accuracy of the Spot Sign on Computed Tomography Angiography as a Predictor of Haematoma Enlargement after Acute Spontaneous Intracerebral Haemorrhage: A Systematic Review | Zendy

Angela Del Giudice | Zendy; Delia D’Amico | Zendy; Jan Sobesky | Zendy; Ian Wellwood | Zendy

Open Access

Accuracy of the Spot Sign on Computed Tomography Angiography as a Predictor of Haematoma Enlargement after Acute Spontaneous Intracerebral Haemorrhage: A Systematic Review

Author(s) -

Angela Del Giudice,

Delia D’Amico,

Jan Sobesky,

Ian Wellwood

Publication year - 2014

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000360754

Subject(s) - medicine , radiology , computed tomography , computed tomography angiography , sign (mathematics) , acute stroke , angiography , cerebral angiography , intracerebral hemorrhage , surgery , glasgow coma scale , mathematical analysis , mathematics , tissue plasminogen activator

A common early complication of intracerebral haemorrhage (ICH) is haematoma enlargement (HE), a strong independent predictor of a poor outcome. Therapeutic options to limit haematoma progression are currently scarce. Haemostatic therapy may be effective in patients with ICH, but it carries the risk of thromboembolic events in unselected patients. Accurate patient selection would, therefore, be of key importance for delivering potentially successful therapeutic strategies. Currently, there is no gold standard to accurately predict HE. The presence of contrast extravasation within the haematoma on computed tomography angiography (CTA), the 'spot sign', has been reported in several studies and seems a particularly promising marker but lacks a standardised evaluation so far.

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