Selective Antegrade Cerebral Perfusion Attenuating the TLR4/NF-κB Pathway during Deep Hypothermia Circulatory Arrest in a Pig Model | Zendy

Zhixian Tang | Zendy; Guangxian Chen | Zendy; Mengya Liang | Zendy; Jian Rong | Zendy; Jianping Yao | Zendy; Xiao Yang | Zendy; Zhongkai Wu | Zendy

Open Access

Selective Antegrade Cerebral Perfusion Attenuating the TLR4/NF-κB Pathway during Deep Hypothermia Circulatory Arrest in a Pig Model

Author(s) -

Zhixian Tang,

Guangxian Chen,

Mengya Liang,

Jian Rong,

Jianping Yao,

Xiao Yang,

Zhongkai Wu

Publication year - 2014

Publication title -

cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 63

eISSN - 1421-9751

pISSN - 0008-6312

DOI - 10.1159/000360694

Subject(s) - tlr4 , neuroprotection , deep hypothermic circulatory arrest , western blot , pharmacology , tunel assay , hypothermia , medicine , signal transduction , apoptosis , biology , anesthesia , cerebral perfusion pressure , immunology , perfusion , inflammation , microbiology and biotechnology , biochemistry , gene

The alteration of the Toll-like receptor/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway during deep hypothermia circulatory arrest (DHCA) has not yet been defined. The aim of this study was to explore the expression of the TLR4/NF-κB pathway cytokine in cerebral injury resulting from DHCA as well as the effect of selective antegrade cerebral perfusion (SACP) on TLR4/NF-κB pathway expression.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research