Analysis of Gene-Gene Interactions Using Gene-Trait Similarity Regression | Zendy

Xin Wang | Zendy; Michael P. Epstein | Zendy; JungYing Tzeng | Zendy

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Analysis of Gene-Gene Interactions Using Gene-Trait Similarity Regression

Author(s) -

Xin Wang,

Michael P. Epstein,

JungYing Tzeng

Publication year - 2014

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000360161

Subject(s) - epistasis , gene , genetics , biology , trait , regression , gene interaction , computational biology , similarity (geometry) , genetic architecture , robustness (evolution) , heritability , genetic association , genome wide association study , quantitative trait locus , genotype , computer science , statistics , mathematics , artificial intelligence , single nucleotide polymorphism , image (mathematics) , programming language

Gene-gene interactions (G×G) are important to study because of their extensiveness in biological systems and their potential in explaining missing heritability of complex traits. In this work, we propose a new similarity-based test to assess G×G at the gene level, which permits the study of epistasis at biologically functional units with amplified interaction signals.

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