Enrofloxacin Enhances the Formation of Neutrophil Extracellular Traps in Bovine Granulocytes | Zendy

Natalja Jerjomiceva | Zendy; H. I. Seri | Zendy; Lena Völlger | Zendy; Yanming Wang | Zendy; Nathalie E. Zeitouni | Zendy; Hassan Y. Naim | Zendy; Maren von KöckritzBlickwede | Zendy

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Enrofloxacin Enhances the Formation of Neutrophil Extracellular Traps in Bovine Granulocytes

Author(s) -

Natalja Jerjomiceva,

H. I. Seri,

Lena Völlger,

Yanming Wang,

Nathalie E. Zeitouni,

Hassan Y. Naim,

Maren von KöckritzBlickwede

Publication year - 2014

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000358881

Subject(s) - neutrophil extracellular traps , enrofloxacin , nocodazole , chemistry , extracellular , respiratory burst , cytochalasin , cytochalasin d , biochemistry , nadph oxidase , apyrase , microbiology and biotechnology , granulocyte , antibiotics , reactive oxygen species , biology , immunology , cytoskeleton , inflammation , cell , ciprofloxacin

Several antibiotics are known for their ability to accumulate in neutrophils and thereby modulate the antimicrobial functions of those cells. This study demonstrates for the first time that an antibiotic, namely the fluoroquinolone enrofloxacin, enhances the formation of bovine neutrophil extracellular traps (NETs). Pharmacologically inactivated NADPH oxidase or peptidyl-arginine deiminase-4 distinctly reduced enrofloxacin-induced NET formation. Additionally, when cells were treated with cytochalasin D or nocodazole, the enrofloxacin-mediated NET induction was abolished, indicating that besides oxidative burst and histone citrullination also actin and microtubule polymerization are involved in this process.

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