The Global Epidemiology of Hereditary Ataxia and Spastic Paraplegia: A Systematic Review of Prevalence Studies | Zendy

Luís Ruano | Zendy; Cláudia Melo | Zendy; Carolina Silva | Zendy; Paula Coutinho | Zendy

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The Global Epidemiology of Hereditary Ataxia and Spastic Paraplegia: A Systematic Review of Prevalence Studies

Author(s) -

Luís Ruano,

Cláudia Melo,

Carolina Silva,

Paula Coutinho

Publication year - 2014

Publication title -

neuroepidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.217

H-Index - 87

eISSN - 1423-0208

pISSN - 0251-5350

DOI - 10.1159/000358801

Subject(s) - medicine , hereditary spastic paraplegia , epidemiology , population , meta analysis , spinocerebellar ataxia , web of science , cerebellar ataxia , pediatrics , disease , ataxia , genetics , psychiatry , environmental health , biology , gene , phenotype

Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive gait impairment, often leading to permanent disability. Advances in genetic research in the last decades have improved their diagnosis and brought new possibilities for prevention and future treatments. Still, there is great uncertainty regarding their global epidemiology.

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