Regulating Chondrogenesis of Human Mesenchymal Stromal Cells with a Retinoic Acid Receptor-Beta Inhibitor: Differential Sensitivity of Chondral Versus Osteochondral Development | Zendy

Solvig Diederichs | Zendy; Kerstin Zachert | Zendy; Patric Raiss | Zendy; Wiltrud Richter | Zendy

Open Access

Regulating Chondrogenesis of Human Mesenchymal Stromal Cells with a Retinoic Acid Receptor-Beta Inhibitor: Differential Sensitivity of Chondral Versus Osteochondral Development

Author(s) -

Solvig Diederichs,

Kerstin Zachert,

Patric Raiss,

Wiltrud Richter

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358723

Subject(s) - chondrogenesis , mesenchymal stem cell , microbiology and biotechnology , chemistry , endochondral ossification , hyaline cartilage , type ii collagen , retinoic acid , cartilage , endocrinology , glycosaminoglycan , chondrocyte , medicine , biology , anatomy , biochemistry , pathology , osteoarthritis , articular cartilage , alternative medicine , gene

Main objective was to investigate whether the synthetic retinoic acid receptor (RAR)-β antagonist LE135 is able to drive in vitro chondrogenesis of human mesenchymal stromal cells (MSCs) or improve differentiation by suppressing hypertrophic chondrocyte development.

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