Open AccessDihydroartemisinin Accentuates the Anti-Tumor Effects of Photodynamic Therapy via Inactivation of NF-κB in Eca109 and Ec9706 Esophageal Cancer Cells
Author(s) -
Yan Jing Li,
Jian Zhou,
Xiao Xue Du,
De Xin Jia,
Chun Long Wu,
Peng Huang,
Yu Han,
Hong Sui,
Wei Xiao,
Lei Liu,
Heng Heng Yuan,
Tingting Zhang,
Wei Zhang,
Rui Xie,
Xiao Lang,
Tao Liu,
Cai Ling Jiang,
Li Ying Wang,
Yu Bai
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000358716
Subject(s) - apoptosis , dihydroartemisinin , photodynamic therapy , cancer research , esophageal cancer , flow cytometry , chemistry , cancer cell , growth inhibition , cancer , western blot , viability assay , mtt assay , microbiology and biotechnology , pharmacology , biology , medicine , biochemistry , immunology , artemisinin , gene , organic chemistry , malaria , plasmodium falciparum
Photodynamic therapy (PDT) is a new treatment for esophageal cancer which has been shown to be effective in the elimination of tumor. However, PDT could induce the activation of nuclear factor-kappa B (NF-κB) in many photosensitizers based PDT, which plays a negative role in PDT. In addition, our previous results have shown that dihydroartemisinin (DHA), which was the most potent one of artemisinin derivatives, has anticancer activity in esophageal cancer cells.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom