Stimulation of Erythrocyte Cell Membrane Scrambling by Mitotane | Zendy

Janin Jacobi | Zendy; Elisabeth Lang | Zendy; Rosi Bissinger | Zendy; Leonie Frauenfeld | Zendy; Paola Modicano | Zendy; Caterina Faggio | Zendy; Majed Abed | Zendy; Florian Läng | Zendy

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Stimulation of Erythrocyte Cell Membrane Scrambling by Mitotane

Author(s) -

Janin Jacobi,

Elisabeth Lang,

Rosi Bissinger,

Leonie Frauenfeld,

Paola Modicano,

Caterina Faggio,

Majed Abed,

Florian Läng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358715

Subject(s) - phosphatidylserine , apoptosis , mitotane , ionomycin , annexin , chemistry , extracellular , annexin a5 , endocrinology , medicine , cell , programmed cell death , biophysics , cytosol , microbiology and biotechnology , stimulation , biology , biochemistry , membrane , phospholipid , adrenocortical carcinoma , enzyme

background: Mitotane (1,1-dichloro-2-[o-chlorophenyl]-2-[p-chlorophenyl]ethane), a cytostatic drug used for the treatment of adrenocortical carcinomas, is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, eryptosis is the suicidal death of erythrocytes, which is typically paralleled by cell shrinkage and breakdown of cell membrane phosphatidylserine asymmetry with subsequent phosphatidylserine exposure at the erythrocyte surface. Eryptosis may be triggered by increase of cytosolic Ca(2+) concentration ([Ca(2+)]i). The present study tested, whether treatment of human erythrocytes with mitotane is followed by eryptosis.

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